The disordered regions of the methyltransferase setd2 govern its function by regulating its proteolysis and phase separation

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• who: Saikat Bhattacharya from the Saikat Bhattacharya1, Jeffrey JLange2, Michaella Levy3, Laurence Florens3, Michael P. Washburn4, and Jerry L. Workman1, * From the Workman Lab, Microscopy, and Proteomics, Stowers Institute for Medical Research, Kansas City, Missouri, USA have published the Article: The disordered regions of the methyltransferase SETD2 govern its function by regulating its proteolysis and phase separation, in the Journal: (JOURNAL) of June/14,/2021
• what: The authors show that SETD2 consists of multiple long disordered regions across its length that cumulatively destabilize the protein by facilitating its proteasomal degradation.
• how: The expression . . .
  

   

  

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