The distribution and function of gde2, a regulator of spinal motor neuron survival, are disrupted in amyotrophic lateral sclerosis

HIGHLIGHTS

  • who: Anna Westerhaus from the University School of Medicine, PCTB1004, NWolfe Street, Baltimore, MD, USA have published the research: The distribution and function of GDE2, a regulator of spinal motor neuron survival, are disrupted in Amyotrophic Lateral Sclerosis, in the Journal: (JOURNAL)
  • what: Taken together this study provides cellular and biochemical evidence that GDE2 distribution and activity is disrupted in ALS supporting the notion that the failure of GDE2-dependent neuroprotective pathways contributes to neurodegeneration and motor neuron loss in disease.
  • how: The demographics of postmortem samples used in this study are provided . . .

     

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