The druggable genome: twenty years later

HIGHLIGHTS

• who: September and colleagues from the University of Oxford, United Kingdom have published the article: The druggable genome: Twenty years later, in the Journal: (JOURNAL)
• what: The authors explore critical considerations for performing structure-based druggability at scale. The authors show how the authors are leveraging automation and cloud computing to expand the internal knowledge graph with residuelevel annotations. The authors discuss how the authors think the arrival of AlphaFold 2 (AF2) will affect target assessment.
• how: By extracting residue-level hotspot scores and mapping the conservation scores to them the authors can . . .
  

   

  

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