HIGHLIGHTS
- who: Xiaoru Ling from the University, Chengdu, China have published the Article: The dynamics of three-dimensional chromatin organization and phase separation in cell fate transitions and diseases, in the Journal: (JOURNAL)
- what: High-order chromatin structure rewiring in diseases can occur due to the following reasons: Point mutations or structural variations in enhancers or target genes, structural variations at chromatin structural factor-binding_sites, and_(3) mutations of chromatin structural factors or other regulatory proteins.
- future: Studies are needed to understand how 3D chromatin dynamics affect the pathogenesis of critical diseases to devise . . .
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