The e3 ubiquitin ligase scffbxl14 complex stimulates neuronal differentiation by targeting the notch signaling factor hes1 for proteolysis

HIGHLIGHTS

• who: Fangfang Chen from the (UNIVERSITY) have published the Article: The E3 ubiquitin ligase SCFFBXL14 complex stimulates neuronal differentiation by targeting the Notch signaling factor HES1 for proteolysis, in the Journal: (JOURNAL) of August/31,/2017
• what: The studies show that deletion of the WRPW motif reduced the interaction between HES1 and FBXL14 (Fig 4B). bearing K24A, K64A, or K71A were also sensitive to CUL1 knockdown, and the changes of protein levels were similar to WT, whereas K83A and K106A mutants showed partial sensitivity to CUL1 knockdown, and the protein levels only increased ⬃60% compared . . .
  

   

  

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