The e46k mutation modulates α-synuclein prion replication in transgenic mice

HIGHLIGHTS

• who: Sara A. M. Holec and colleagues from the Editor: AMabbott, University of Edinburgh, Institute for Neurosciences, University of California, San FranciscoInstitute for Neurosciences, University of California, San Francisco have published the research: The E46K mutation modulates u03b1-synuclein prion replication in transgenic mice, in the Journal: (JOURNAL)
• what: The authors investigated effect of E46K in which causes PD on strain biology to determine how patient`s genetic background can impact disease. This work showed that for yeast strains to propagate, the fibril size must exceed a minimum ns prior to budding, otherwise the fibril . . .
  

   

  

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