The effect of osteoporotic and non-osteoporotic individuals’ t cell-derived exosomes on osteoblast cells’ bone remodeling related genes expression and alkaline phosphatase activity

HIGHLIGHTS

  • who: Mohammad Hasan Omidvar from the Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran have published the article: The effect of osteoporotic and non-osteoporotic individualsu2019 T cell-derived exosomes on osteoblast cellsu2019 bone remodeling related genes expression and alkaline phosphatase activity, in the Journal: (JOURNAL) of 30/06/2022
  • what: T_cell exosomes obtained from osteoporotic patients could alter osteoblastic function (ALP activity) and gene_expression through downregulation of essential genes for bone formation such as Runx2, type I collagen, osteopontin, and osteocalcin, consequently propelling cells towards osteoclastogenesis.
  • how: The . . .

     

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