The effects of pegylation on lnp based mrna delivery to the eye

HIGHLIGHTS

• who: Renee C. Ryals and collaborators from the Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland have published the paper: The effects of PEGylation on LNP based mRNA delivery to the eye, in the Journal: PLOS ONE of 29/Oct/2020
• what: The authors show that particles with less PEG (0.5%) and larger in size (~150 nm) facilitate the highest levels of protein expression post-subretinal and intravitreal delivery. The authors demonstrate that neither apoE adsorption, nor MERTK dependent phagocytosis are critical for LNP intracellular delivery to the RPE. The . . .
  

   

  

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