HIGHLIGHTS
- who: Burkhard Kleuser from the DepartmentUniversity of have published the Article: The Enigma of Sphingolipids in Health and Disease, in the Journal: (JOURNAL) of 12/Oct/2018
SUMMARY
As peritoneal B cells are the major source of natural serum immunoglobulin (Ig) A, downregulation of S1PR4 reduces the production of intestinal IgA. A critical role of S1PR4 has been detected in mast cells. Olivera et_al were able to show that, although the S1PR4 is dispensable for mast cell degranulation and cytokine production, this receptor subtype regulates passive systemic anaphylaxis in mice. Bioactive sphingolipids have . . .
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