HIGHLIGHTS
- who: Yong Jiang from the including viral hepatitis, liver cirrhosis, and other systemic or gastrointestinal diseases [4, ]There are also marked geographical differences in the ICC incidence throughout the world, and epidemiological differences have been observed even when examining populations exposed to similar risk factors. These differences may be attributable to ICC misclassification in at least some cases. Consistently, ICCs have been diagnosed as cases of hepatocellular carcinoma, mixed cancer, or cancer of unknown primary origin, while Klatskin tumors are occasionally misclassified as ICC [4, , ]. Definitive diagnosis of ICC in the more advanced stages of the disease . . .
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