The er aminopeptidases, erap1 and erap2, synergize to self-modulate their respective activities

HIGHLIGHTS

• who: Adrian Martu0131u00b4n-Esteban from the Institut National la Santu00e9 et la Recherche Mu00e9dicale (INSERM), France Department of Pathology, Immunopathology Division, Johns Hopkins University, Baltimore have published the article: The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities, in the Journal: (JOURNAL)
• what: The authors demonstrate that the optimal ligands for either enzyme act as inhibitors of the other enzyme. The authors propose a mechanism for how ERAP1 and ERAP2 synergize to modulate their respective activities and shape the MHC-I peptidome by generating optimal peptides for presentation. One limitation of . . .
  

   

  

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