The extreme c terminus of the pseudomonas aeruginosa effector exoy is crucial for binding to its eukaryotic activator, f-actin

HIGHLIGHTS

• who: Alexander Belyy from the (UNIVERSITY) have published the research: The extreme C terminus of the Pseudomonas aeruginosa effector ExoY is crucial for binding to its eukaryotic activator, F-actin, in the Journal: (JOURNAL) of May/26,/2018
• what: Utilizing yeast phenotype analysis, site-directed_mutagenesis, functional biochemical assays, and confocal microscopy, the authors demonstrate that the last nine amino_acids of the C terminus of ExoY are crucial for the interaction with F-actin and, consequently, for ExoY's enzymatic activity in_vitro and toxicity in a yeast model. The authors demonstrated that ExoY can bind to . . .
  

   

  

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