The fatty acid elongase elovl6 is crucial for hematopoietic stem cell engraftment and leukemia propagation

HIGHLIGHTS

• who: Yusuke Kiyoki from the Graduate SchoolUniversity of Tsukuba, Tennodai, Tsukuba, Ibaraki, Japan have published the research: The fatty acid elongase Elovl6 is crucial for hematopoietic stem cell engraftment and leukemia propagation, in the Journal: (JOURNAL) of 19/Oct/2022
• what: This study reports novel outcomes in normal HSCs and transformed hematopoietic cells following lipid metabolic changes induced by Elovl6 deficiency.
• how: To determine whether Elovl6 loss alters PI3K activation the authors examined AKT phosphorylation a representative readout of PI3K activity in WT and E6KO MA9 cells before and after CXCL12 stimulation.
 



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