The first structure of human mthfd2l and its implications for the development of isoform‐selective inhibitors

HIGHLIGHTS

• who: Very Important Paper and colleagues from the (UNIVERSITY) have published the research work: The First Structure of Human MTHFD2L and Its Implications for the Development of Isoformu2010Selective Inhibitors, in the Journal: (JOURNAL)
• what: The authors propose this to be an important factor for the enhanced inhibition of TH7299 towards MTHFD2L, and as additional structural comparisons indicate, also MTHFD1. As no structural information existed prior to the current study, the authors aimed to solve the X-ray_crystal_structure of MTHFD2L in complex with TH7299 to gain insight into the structural reasons for the significant differences in . . .
  

   

  

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