HIGHLIGHTS
- who: Danilo Predes and colleagues from the Instituto Ciu00eancias Biomu00e9dicas, Universidade Federal do Rio Janeiro, Rio Janeiro, Brazil have published the paper: The Flavonol Quercitrin Hinders GSK3 Activity and Potentiates the Wnt/-Catenin Signaling Pathway, in the Journal: (JOURNAL)
- what: Next the authors show that Wnt3a-synaptogenic effect in hippocampal neurons in culture which is blocked by XAV939. treatment also rescues hippocampal synapse loss induced by intracerebroventricular injection of amyloid-u03b2 oligomers (Au03b2O) in mice. The authors characterize quercitrin as a Wnt/u03b2-catenin potentiator and a promising therapeutic candidate for treating AD. Once the . . .
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