HIGHLIGHTS
- who: jac from the Department of Chemistry, Dartmouth College, Hanover, NH, USA have published the research work: The Free Internet Journal, in the Journal: (JOURNAL)
- what: We have synthesized eight novel indoloquinones, 17a-d and 18a-d for DNA binding studies.
SUMMARY
The antitumor activity and DNA affinity of amino-substituted quinones is well established and several drugs in this category have seen utility in the cancer clinic; for example, mitomycin,5,6 ametantrone,7 mitoxantrone,8,9 pixantrone,10-12 and WEHI-150 13,14. Similarly, compounds 17b and 17c . . .
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