The gαi-giv binding interface is a druggable protein-protein interaction

HIGHLIGHTS

• who: Vincent DiGiacomo from the (UNIVERSITY) have published the Article: The Gαi-GIV binding interface is a druggable protein-protein interaction, in the Journal: (JOURNAL) of 22/05/2017
• what: The properties of the Gαi-GIV interaction predicted by this model have been extensively validated using site-directed_mutagenesis and NMR spectroscopy46. The authors focused the efforts on SCIEntIFIC REPOrTS | 7: 8575 | DOI:10.1038/s41598-017-08829-7 the characterization of NF023 binding, which is predicted to extensively overlap with the GIV binding_site by docking onto the SwII/α3 cleft and extending into . . .
  

   

  

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