The g protein coupled receptor cxcr4 designed by the qty code becomes more hydrophilic and retains cell signaling activity

HIGHLIGHTS

• who: Lotta Tegler from the Center for BitsLinköping University have published the research work: The G protein coupled receptor CXCR4 designed by the QTY code becomes more hydrophilic and retains cell signaling activity, in the Journal: Scientific Reports Scientific Reports of 26/Nov/2019
• what: The authors show that the QTY code can successfully be used to design a more hydrophilic form of CXCR4 that retains cellular signaling activity in HEK293 cells by replacing only 29 lipid-facing transmembrane L, I, V and F residues.

SUMMARY

Such large-scale changes . . .

 



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