The gasdermin d n-terminal fragment acts as a negative feedback system to inhibit inflammasome-mediated activation of caspase-1/11

HIGHLIGHTS

• who: The Gasdermin D N-terminal and collaborators from the Queen`s University Belfast, Research Portal: Link to publication record in Queen`s University Belfast Research Portal have published the research work: The Gasdermin D N-terminal fragment acts as a negative feedback system to inhibit inflammasome-mediated activation of Caspase-1/11, in the Journal: PNAS of June/23,/2022
• what: While a previous study has suggested that the cleavage-site tetrapeptide of GSDMD binds to the catalytic groove of caspase-1 , the studies showed that the RFWK residues of the u03b21-u03b22 loop . . .
  

   

  

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