The genomic basis of childhood t-lineage acute lymphoblastic leukaemia

HIGHLIGHTS

• Who: Posted Date October et al. from the StJude Research, University of Perugia have published the paper: The genomic basis of childhood T-lineage acute lymphoblastic leukemia, in the Journal: (JOURNAL)
• How: To identify genomic drivers of each cluster the authors examined associations between subtypes and genomic alterations identified from analysis of sequence and structural DNA variants (SV). The authors analyzed the differentiation stage of each T-ALL subtype by projecting gene_expression signatures onto single cell RNA (scRNA) and assay for transposase-accessible chromatin (ATAC) sequencing data of normal thymi (n=3) and BM samples . . .
  

   

  

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