HIGHLIGHTS
SUMMARY
Although epidemiologic studies on MNDs have been published in the United_States and Europe, their incidence, prevalence, and burden are not well known because the diseases are rare. Although it varies according to age, sex, and region, the peak incidence of ALS is at ~70 years, the incidence rate is 1.7 per 100,000 person-years, and the prevalence is 4.5 per 100,000 people. According to the 2016 Global Burden of Diseases (GBD) estimates, the incidence rate of all age was 0.78 per 100 000 person-years for MNDs. The age . . .
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