HIGHLIGHTS
SUMMARY
The phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway and adjust ribosome biogenesis and thus cell growth and proliferation accordingly (Iadevaia et_al, 2014; Yang et_al, 2019). mTOR phosphorylates ribosomal protein S6 kinases (S6Ks) and eukaryotic initiation factor (eIF) 4E-binding proteins (4EBPs) among others, thereby promoting translation (Valvezan and Manning, 2019). Literature suggests that mTOR is also involved in the transcriptional regulation of RiBis and/or RPs (Mayer and Grummt, 2006; Chauvin et_al, 2014; Rosario et_al, 2020). In contrast, Fhl1 and Ifh1 are thought to be specific regulators of RPs (Jorgensen . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.