The golgi-localized sphingosine-1-phosphate phosphatase is indispensable for leishmania major

HIGHLIGHTS

• who: Brian Okundaye from the DepartmentTech University have published the research work: The Golgi-localized sphingosine-1-phosphate phosphatase is indispensable for Leishmania major, in the Journal: Scientific Reports Scientific Reports

SUMMARY

While many eukaryotes including Saccharomyces cerevisiae, Homo sapiens, Mus musculus, and Arabidopsis thaliana possess two SPP isoforms, only one putative SPP is identified in L major and other trypanosomatids. To determine if L major SPP possesses the expected enzymatic activity, the authors cloned the gene into a pMAL-c5x vector to generate a N-terminal maltose binding protein (MBP) tagged version . . .

 



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