The histone acetyltransferase tip60 interacts with c-myb and inactivates its transcriptional activity in human leukemia*

HIGHLIGHTS

• who: Huiwu Zhao from the Huiwu Zhao1, Shenghao Jin, and Alan MGewirtz† From the Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania , Background: Transcription factors regulate their target genes by recruiting histone-modifying proteins. Results: Histone acetyltransferase , binds transcription factor c-Myb to suppress c-Myb activity. Conclusions: c-Myb activity is regulated by TIP60. Significance: These findings broaden the understanding of how c-Myb is regulated and suggest that dysregulated or mutated , may contribute to leukemogenesis. The histone acetyltransferase , is a coregulator of transcription factors and is implicated in . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.