The igh eµ-mar regions promote ung-dependent error-prone repair to optimize somatic hypermutation

HIGHLIGHTS

• who: Ophu00e9lie A. Martin from the University of Texas Health Science Center at San Antonio, United States have published the paper: The IgH Eu00b5-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation, in the Journal: (JOURNAL)
• what: While also modifying sense and antisense transcription pattern, the study shows that MARsEu00b5deletion does not impede AID footprint but rather some of repair mechanisms acting downstream from the U-G mismatch.
• how: For this the authors used two complementary sequencing methods the first one based on classical Sanger approach and GS junior . . .
  

   

  

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