The immune landscape of high-grade brain tumor after treatment with immune checkpoint blockade

HIGHLIGHTS

• who: Jang Hyun Park and collaborators from the Flinders University, Australia have published the research work: The immune landscape of high-grade brain tumor after treatment with immune checkpoint blockade, in the Journal: (JOURNAL)
• what: The authors propose that accumulation of anti-inflammatory macrophages suppresses CD8 T_cells via amino_acid deprivation. and found that although Ccl3 and Ccl4 were downregulated by aPD-1 treatment, Ccl5 expression was strongly augmented by aPD-1 . The authors propose that CCL5-mediated immunosuppression may affect re-exhaustion of CD8 T_cells through macrophages. The authors propose CCL5 and LAG3 as promising . . .
  

   

  

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