The immune microenvironment of hpv-positive and hpv-negative oropharyngeal squamous cell carcinoma: a multiparametric quantitative and spatial analysis unveils a rationale to target treatment-naïve tumors with immune checkpoint inhibitors

HIGHLIGHTS

SUMMARY

The role of tissue-resident memory (­ TRM) CD8+ T_cells coexpressing the CD103 marker has recently emerged as a favorable prognostic indicator in many cancer types, included HNSCC. The authors advance a potential new rationale for the incorporation of ICI in the locoregional therapy strategies for patients with heavily infiltrated treatment-naïve OPSCC, and for the combined use of ICI and tumor-specific T_cell response inducers or tumor-associated macrophages (TAM) modulators for the non-inflamed counterparts. The ratios between CD8 T_cells and TILs, CD8 T_cells and exhausted CD8 cells, and CD8 and T . . .

 



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