HIGHLIGHTS
- who: Andrew Blauvelt from the Oregon Medical Research Center, SW Locust St, Suite G, Portland, OR, USA have published the research: The Immunologic Role of IL-17 in Psoriasis and Psoriatic Arthritis Pathogenesis, in the Journal: (JOURNAL)
- what: Many cytokines are involved in psoriasis development; however, data identify IL-17A as the major effector cytokine driving pathogenesis.
- how: Evidence of this indirect effect was observed in clinical trials of etanercept in which genomic data indicated that etanercept efficacy was dependent on downregulation of IL-17A or IL-17A signaling .
SUMMARY
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