HIGHLIGHTS
SUMMARY
ETs and EA demonstrated in_vitro great potential in the treatment of oxidative stress-mediated human diseases, comparable to that of urolithins, but in_vivoonly urolithins proved to be responsible for the beneficial effects. In the present review, the authors aimed to report relevant and recent aspects of the role of ETs and their microbiota-derived metabolites in gut and brain health documented on in_vitro, in_vivo, and in some new clinical studies. Major keywords, such as "polyphenols", "hydrolysable tannins", "ellagitannins", "ellagic acid", "urolithins", "chemical structure", "sources", "metabolism", "bioavailability", "biological activities", "antioxidant", "anti-inflammatory", "neuroprotective", "anti-cancer . . .
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