HIGHLIGHTS
SUMMARY
Closer analysis revealed that while in wild_type mice, astrocyte endfeet co-localized strongly with α-SMA positive smooth muscle cells (SMCs) in small arterioles, in the astrocyte-specific laminin KO strain, the number of α-SMApositive cells was markedly reduced. When challenged by chronic mild hypoxia (CMH, 8% O2 for periods up to 14 days), in contrast to wild_type mice, which mount a strong arteriogenic remodeling response resulting in increased arteriolar density, β4-EC-KO mice showed reduced arteriolar remodeling that correlated with attenuated transforming growth factor (TGF)-β signaling. This was tested by comparing EAE severity . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.