The impact of microfluidics in high-throughput drug-screening applications

HIGHLIGHTS

SUMMARY

    The poor correlation between preclinical in_vitro and in_vivo data with clinical trials remains a major concern. The culture conditions are too simple to mimic an in_vivo microenvironment. Although 2D cell cultures are still widely used and play a big role in this field, 3D cell cultures are progressively receiving more attention, as several types of cells need to grow in 3D systems to resemble more closely in_vivo conditions, such as cellular events and disease progression. Other cell types need to grow in 3D systems to resemble more closely in_vivo conditions. Tung et_al, for example . . .

     

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