HIGHLIGHTS
SUMMARY
The cerebrospinal fluid (CSF) in the subarachnoid space flows into interstitial spaces (ISS) along the pial-glial basement membranes also named perivascular spaces (PVS) and mixes with the interstitial fluid (ISF). In this study, using a model of SAH, the authors demonstrated apoptosis of endothelial cells, activation of astrocytes, degradation of capillary basement membranes and impairment of IPAD after SAH. In Experiment 2, 89 rats were divided into Sham and SAH groups (n=35 each group), and 19 rats died after SAH. Measurement of brain water content Five rats were randomly selected from Sham . . .
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