HIGHLIGHTS
- who: Pearls, and Glenn C., Telling from the State University have published the research: The Importance of Prions, in the Journal: (JOURNAL) of January/31,/2013
SUMMARY
Recent experimental studies using mass spectrometry analysis coupled with hydrogen-deuterium exchange indicate a PrPSc conformation radically different from PrPC, which is at odds with the "bhelical" and "spiral" models, in which PrPSc retains substantial amounts of native a-helices. Undoubtedly, the capacity to amplify highly infectious prions using recPrP by PMCA will greatly facilitate the isolation of PrPSc for future structural studies. Recent studies in . . .
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