HIGHLIGHTS
SUMMARY
It has been reported that collective invasion occurs in a cancer cell cluster consisting of polyclonal cancer cells. The authors established subclones with different invasive potential from a skin SCC line, A431 cells, which consist of heterogeneous cells and can invade as a polyclonal cell cluster. The mixed spheroids of the high- and low-invasive subclones showed that the high-invasive STAT1-activated subclonal cells were located at the invasive front of the invasive protrusion and led to collective invasion with the low-invasive sub-clonal cells. Establishment of subclones with high- or low . . .
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