The interplay of four main pathways recomposes immune landscape in primary and metastatic gastroenteropancreatic neuroendocrine tumors

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SUMMARY

    Currently, the prerequisites for good immunotherapy were the preexistence of immune checkpoints and the higher infiltration of effector CD8 T_cells. Constructing the PC_Score and PI_Score Scoring System to Evaluate Individual GEP-NENs Gene Set Variation Analysis and Functional Annotation 1) After obtaining the odds radios of each specific gene score, the authors then define the PC_Score and PI_Score of each patient: PC_Score/PI_Score=(bi × Expi),where i means the specific phenotype-related genes. The authors used the screened specific marker including 9 markers associated with CAFs and 6 makers associated with CD4 T-cell . . .

     

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