The intracellular trafficking mechanism of lipofectamine-based transfection reagents and its implication for gene delivery

HIGHLIGHTS

  • who: Francesco Cardarelli from the Center for NanotechnologyUniversity of have published the research work: The intracellular trafficking mechanism of Lipofectamine-based transfection reagents and its implication for gene delivery, in the Journal: Scientific Reports Scientific Reports
  • how: This result is made possible by the emergence of a peculiar random Brownian motion of Lipofectamine-containing vesicles within the cytoplasm.

SUMMARY

    Chinese hamster ovarian (CHO) cells were seeded in 6-wells plates and incubated with LFN/DNA (fur- ther experimental details can be found in the Supporting Information). Phase III is characterized by . . .

     

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