The intrinsically disordered protein tgist from toxoplasma gondii inhibits stat1 signaling by blocking cofactor recruitment

HIGHLIGHTS

• who: Zhou Huang from the Washington University, La Jolla, CA, USA have published the Article: The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors investigate how the pathogen effector TgIST blocks STAT1-mediated gene_expression. The studies provide new insight into STAT1-mediated gene_expression and define a unique mechanism for how pathogens selectively disrupt interferon signaling.
• how: The authors compared wild-type mutant and complemented lines in the type II Pru strain during infection of C57/BL6 mice . . .
  

   

  

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