The ion channel trpa1 is a modulator of the cocaine reward circuit in the nucleus accumbens

HIGHLIGHTS

• What: The authors showed that both knockdown of TRPA1 expression in the NAc and treatment with a TRPA1 antagonist reduced drug-seeking behavior and reward effects in mice that had received cocaine. Mechanistically, the authors show that pharmacological inhibition of TRPA1 decreases cocaine-induced increase in DA concentration by rescuing the synaptic dopamine reuptake. Mechanistically, the authors demonstrate that cocaine intake increases the sEPSC amplitude in D1R-MSNs but does not do so upon TRPA1 KD. The authors focused on TRPA1 function in the neurons of the nucleus accumbens.
• Who: Young-Jung Kim from the . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.