HIGHLIGHTS
- who: Afrooz Dabbaghizadeh et al. from the Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H A , Canada have published the paper: The J Domain of Sacsin Disrupts Intermediate Filament Assembly, in the Journal: (JOURNAL)
- what: Having studied the mechanism using NF assembled in vitro from purified NF proteins the authors report that the SacsJ interacts with NF proteins to disassemble NFL filaments and to inhibit their initial A cell-penetrating peptide derived from this SacsJ-myc-TAT was efficient in disassembling NF bundles in cultured Sacs-/- motor neurons restoring the . . .
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