The jak1 selective inhibitor abt 317 blocks signaling through cytokine receptors to reverse autoimmune diabetes in nod mice

HIGHLIGHTS

• who: Tingting Ge from the Yonsei University Health System, Cardiff University, United Kingdom have published the article: The JAK1 Selective Inhibitor ABT 317 Blocks Signaling Through Cytokine Receptors to Reverse Autoimmune Diabetes in NOD Mice, in the Journal: (JOURNAL)
• what: The authors propose that ABT 317 acts by inhibiting common g chain cytokinedependent proliferation of CD8+ T_cells in the islets, instead of CD4 + T-cell proliferation. The authors show that treatment of NOD mice with a JAK1 selective inhibitor, ABT 317, blocked MHC class 1 upregulation on b_cells and inhibited common g chain cytokine effects . . .
  

   

  

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