The ku-parp14 axis differentially regulates dna resection at stalled replication forks by mre11 and exo1

HIGHLIGHTS

• who: Ashna Dhoonmoon from the (UNIVERSITY) have published the paper: The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1, in the Journal: (JOURNAL) of 25/01/2022
• what: The authors show that the mono-ADP-ribosyltransferase PARP14 is a critical co-factor of MRE11. The authors show that the KU complex binds reversed forks and protects them against EXO1-catalyzed degradation. The authors show that PARP14 itself binds nascent DNA upon replication stress, and PARP14-deficient cells have defective MRE11 recruitment to stalled replication forks, suggesting that PARP14 . . .
  

   

  

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