The longitudinal dynamics and natural history of clonal haematopoiesis

HIGHLIGHTS

  • who: Margarete A. Fabre from the (UNIVERSITY) have published the research: The longitudinal dynamics and natural history of clonal haematopoiesis, in the Journal: (JOURNAL) of 12/08/2021
  • what: The authors show that mutations driving faster clonal growth carry a higher risk of malignant progression.
  • how: The authors analysed 1593 blood DNA samples from 385 adults aged 55-93 years at the time of entry into the SardiNIA longitudinal study26. To corroborate observations from the three individuals depicted in Fig 3 the authors conducted additional phylodynamic analyses of trees derived from 1461 whole . . .

     

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