The m-phase regulatory phosphatase pp2a-b55δ opposes protein kinase a on arpp19 to initiate meiotic division

HIGHLIGHTS

• who: Tom Lemonnier from the CNRS have published the article: The M-phase regulatory phosphatase PP2A-B55δ opposes protein kinase A on Arpp19 to initiate meiotic division, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• how: To ensure that the early action of PP2A-B55δ is disconnected from its late function the authors investigated whether Arpp19 dephosphorylation at S109 is independent of Cdk1 activity.

SUMMARY

In this species, Arpp19 phosphorylation at S109 by PKA is critical to maintain oocytes arrested in prophase. Within this motif, S67 is phosphorylated 2 by Gwl to . . .

 



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