The m6a reader ythdc1 and the rna helicase ddx5 control the production of rhabdomyosarcoma-enriched circrnas

HIGHLIGHTS

SUMMARY

For a set of circRNAs, such an increase is due to the raised expression of the m6A machinery, which the authors also find to control the proliferation activity of RMS cells. By applying CIRI2 algorithm28 the authors identified 2897 circRNAs expressed in wild-type myoblasts, 4935 in RD cells, and 3811 in RH4 cells (Supplementary Fig 1a). Interestingly, comparing RMS and control myoblasts, while the amount of up- and downregulated linear mRNAs was the same, circRNAs displayed an evident predominance of upregulated species in cancer cells (Fig 1b, Supplementary Fig 1b). The authors found . . .

 



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