The making of multivalent gamma delta tcr anti-cd3 bispecific t cell engagers

HIGHLIGHTS

• who: Eline van Diest et al. from the Johannes Gutenberg Mainz, Germany have published the research: The making of multivalent gamma delta TCR anti-CD3 bispecific T cell engagers, in the Journal: (JOURNAL)
• what: GABs are made by the fusion of the ectodomains of a gdTCR to an anti-CD3 single chain variable fragment (scFv) (gdECTO-aCD3), here the authors explore alternative designs with the aim to enhance GAB effectivity. The authors show that dimers are a natural by-product of the recently reported gdECTO-aCD3 design, and that gdECTO-aCD3-dimers have higher activity . . .
  

   

  

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