The mechanism-based inactivation of cyp3a4 by ritonavir: what mechanism?

HIGHLIGHTS

• who: Nancy H. C. Loos et al. from the The Netherlands Cancer Institute, Division of, CX Amsterdam, The Netherlands, Utrecht University, CS Utrecht, The Netherlands have published the research: The Mechanism-Based Inactivation of CYP3A4 by Ritonavir: What Mechanism?, in the Journal: (JOURNAL)
• what: In this review, the authors focus on CYP3A, which 2 of 24 is responsible for the primary metabolism of about 50% of drugs due to its extremely broad substrate specificity . In the following paragraphs, the authors provide some further background on the development and use of ritonavir in view of its . . .
  

   

  

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