The mechanistic immunosuppressive role of the tumour vasculature and potential nanoparticle-mediated therapeutic strategies

HIGHLIGHTS

  • who: Zakaria Elias Ileiwat from the Sun Yat-sen Cancer Center (SYSUCC), China have published the Article: The mechanistic immunosuppressive role of the tumour vasculature and potential nanoparticle-mediated therapeutic strategies, in the Journal: (JOURNAL)
  • what: Recruitment of these cells is mostly mediated by PDGF-b secreted by endothelial cells but in situ hybridisation from mouse tumour models demonstrated that endothelial cells did not lack PDGF-b expression .
  • how: Data showed that MMP2 and MMP9 expression was positively correlated to tumour invasion depth venous invasion and increased tumour size (over 4cm) . These results . . .

     

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