HIGHLIGHTS
- who: Prabhakar Arumugam from the University of Melbourne, Australia have published the research: The mitochondrial gene-CMPK2 functions as a rheostat for macrophage homeostasis, in the Journal: (JOURNAL)
- what: In line with the previous study on the robust induction of type I IFN response in Mtb-infected macrophages , the authors show that CMPK2, an ISG, is highly induced immediately following infection and is rapidly regulated to baseline levels in human macrophages. The authors demonstrate a significant shift in the metabolic status of CMPK2-modulated cells (KD and OE) toward rapid energy production via glycolysis and . . .
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