The mitochondrial unfolded protein response (upr

HIGHLIGHTS

• who: Joseph R. Inigo from the (UNIVERSITY) have published the paper: The mitochondrial unfolded protein response (UPR, in the Journal: (JOURNAL)
• what: In this review the authors discuss how mitochondria become dysfunctional in and highlight tumor-promoting functions of key components of u00adUPRmt. The current review elaborates the development of mitochondrial dysfunction in cancer and discusses how mitochondrial dysfunction and elevated mtROS benefit tumor growth. It is possible that this study has detected a transient interaction in which HSP60 is mediating the folding of mtHSP70 that has been recently imported into the mitochondria.
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