The molecular mechanism of positive allosteric modulation at the dopamine d1 receptor

HIGHLIGHTS

SUMMARY

Allosteric binding_sites are typically located at distinct and divergent regions of the receptors, allowing allosteric drugs to avoid direct competition with orthosteric agonists as well as to exhibit Int. D1R PAMs PAMs may be able to exert their allosteric effect without inducing tachyphylaxis, a side may be able to exert their allosteric effect without inducing tachyphylaxis, a side effect effect observed in some D1R agonists. observed in some D1R agonists. The authors collected approximately 95 µs of MD simulation data in total for four conditions: D1R/dopamine-alone, D1R/dopamineLY3154207, D1R/apomorphine-alone, and . . .

 



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